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Epidermolysis bullosa simplex with mottled pigmentation
Author(s) -
COLEMAN R.,
HARPER J.I.,
LAKE B.D.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00265.x
Subject(s) - dermatology , epidermolysis bullosa simplex , epidermolysis bullosa , medicine , trunk , pathology , epidermis (zoology) , histology , dyskeratosis , anatomy , biology , hyperkeratosis , ecology
Summary A family in which epidermolysis bullosa simplex and mottled pigmentation are inherited as an autosomal dominant disorder is described. Clinical features include: non‐scarring blistering, mainly affecting the limbs, mottled pigmentation, predominantly affecting the trunk and neck, warty hyperkeratotic papules of the palms and soles, small red scaly plaques, and skin atrophy. Histology showed an atrophic epidermis, basal cell lysis and significant colloid body formation in an infant from the family.