Premium
Immunohistochemical evaluation of epidermis overlying basal cell carcinomas
Author(s) -
KIKUCHI A.,
SAKURAOKA K.,
SHIMIZU H.,
NISHIKAWA T.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00260.x
Subject(s) - epidermis (zoology) , pathology , biology , immunohistochemistry , dermis , stratum spinosum , anatomy , medicine , stratum corneum
Summary We have examined the character and carcinogenic properties of the normal‐appearing epidermis overlying basal cell carcinomas by immunohistochemical methods, employing a series of monoclonal antibodies. The labelling index was significantly increased in the atrophic epidermis overlying basal cell carcinomas (solid type, n =20). compared with the epidermis overlying or adjacent to squamous cell carcinoma ( n =20). keratoacanthoma ( n = 10). dermatofibroma ( n =10), neurofibroma ( n = 10). soft fibroma ( n =10). pyogenic granuloma ( n =10) and cutaneous leiomyoma ( n =5). Cells which expressed epidermal growth factor (EGF) receptor were detected in all layers of the epidermis over the basal cell carcinomas, hut not the other tumours. Basement membrane‐related antigens, including bullous pemphigoid antigen and GB3 antigen, were decreased in the epidermis. AEl. the monoclonal antibody against basal cell keratin, reacted with the uppermost layers of the normal‐appearing epidermis overlying the basal cell carcinomas. ICAM‐1 expression was very weak in the overlying epidermis. The dermis subjacent to the proliferating epidermis showed staining for transforming growth factor‐α (TGF‐α). strong positive PECAM‐1 staining of endothelium. and numerous HLA‐DR‐positive cells. From these results, we suggest that the proliferative activity in the epidermis overlying basal cell carcinomas is not a state induced by the dermal infiltrate, but represents carcinogenic activity of the epidermis.