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Paraneoplastic pemphigus in a child with a T‐cell lymphoblastic lymphoma
Author(s) -
RYBOJAD M.,
LEBLANC T.,
FLAGEUL B.,
BERNARD PH.,
MOREL P.,
SCHAISON G.,
D'AGAY M.F.,
BORRADOR L.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00202.x
Subject(s) - lymphoblastic lymphoma , medicine , pemphigus , paraneoplastic pemphigus , lymphoma , dermatology , immunology , t cell , antibody , autoantibody , immune system
Summary We report a child with a T‐cell lymphoblastic lymphoma, and a widespread erosive mucocutaneous eruption, whose clinical and immunopathological features were consistent with a diagnosis of paraneoplastic pemphigus. Direct immunofluorescence showed deposition of C3 in the epidermal intercellular spaces, and in a linear pattern along the dermo‐epidermal junction. Circulating autoantibodies binding in a pemphigus‐like pattern to mouse urinary bladder epithelium were found. By Western immunobiotting, the patient's serum recognized two epidermal polypeptides with molecular weights of 210 and 190 kDa. No reactivity with the 230‐kDa bullous pemphigoid antigen and the 250‐kDa desmoplakin I antigen was found.