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Bullous eruption of systemic lupus erythematosus: a clinicopathological study of four cases
Author(s) -
BURROWS N.P.,
BHOGAL B.S.,
BLACK M.M.,
RUSTIN M.H.A.,
ISHIDAYAMAMOTO A.,
KIRTSCHIG G.,
JONES R. RUSSELL
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00180.x
Subject(s) - epidermolysis bullosa acquisita , lamina densa , medicine , immunoelectron microscopy , pathology , lamina lucida , basement membrane , dermatology , dapsone , antibody , lupus erythematosus , immunology , immunohistochemistry , autoantibody , basal lamina , ultrastructure
Summary We describe the clinical, histological and immunopathological features of four female patients with the bullous eruption of systemic lupus erythemutosus (bullous SLE). Three patients had circulating anti‐basement membrane zone (BMZ) antibodies, and Western blot analysis in two cases revealed binding to type VII collagen. Immunoeiectron microscopy in one of these patients demonstrated deposition of antibody in the lamina densa and sublamina densa regions, thus sharing immunopatho‐logical features with epidermolysis bullosa acquisita (KBA). The vesiculobullous lesions developed 8 months to 6 years after the initial symptoms of SLE, and cleared promptly with dapsone treatment.