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Response of psoriasis to psoralen‐UVB photochemotherapy
Author(s) -
SAKUNTABHAI A.,
DIFFEY B.L.,
FARR P.M.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00174.x
Subject(s) - psoriasis , newcastle upon tyne , psoralen , dermatology , medicine , family medicine , history , library science , art history , biology , computer science , dna , genetics
Summary The effect of psoralen in combination with 31 1 nm (UVB) radiation was studied in five subjects with normal skin and 10 patients with psoriasis involving both forearms. Treatment with oral 8‐methoxypsoralen augmented the UVB erythemal response at 6 h after irradiation, but had no effect at 24–72 h. In eight of the nine patients who completed the trial, lesions of psoriasis on the arms treated with psoralen‐LlVB cleared hefore lesions on the arms treated with UVB alone. This study has shown that psoralen in comhination with UVB has an erythemal effect on normal skin, and a therapeutic effect in psoriasis which is greater than the response to UVB alone.