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Soluble intercellular adhesion molecule‐1 levels in patients with psoriasis
Author(s) -
SCHOPF R.E.,
NAUMANN S.,
REHDER M.,
MORSCHES B.
Publication year - 1993
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1993.tb00143.x
Subject(s) - psoriasis , psoriasis area and severity index , intercellular adhesion molecule 1 , medicine , adhesion , monoclonal antibody , intercellular adhesion molecule , icam 1 , immunology , inflammation , antibody , gastroenterology , dermatology , cell adhesion molecule , chemistry , cell adhesion , organic chemistry
Summary A newly developed ELISA was used to detect and quantify the presence of a soluble form of intercellular adhesion molecule‐1 (sICAM‐1) in the circulation of healthy individuals compared with patients with psoriasis vulgaris. Seventeen psoriatic patients were studied. The extent of skin lesions was rated by the psoriasis area and severity index (PASI). Seventeen age‐ and sex‐matched healthy individuals served as controls. Serum levels were measured by an ELISA technique utilizing an anti‐ICAM‐1 murine monoclonal antibody bound to the solid phase, and a second, peroxidase‐conjugated monoclonal antibody reacting with sICAM‐1. Serum levels in controls were 358.8±87.9 ng/ml sICAM‐1, and 480.5±133.6 ng/ml in psoriatics (mean±SD; P =0.02). In psoriasis. sICAM‐1 levels were found to be directly proportional to the PASI score ( y =363.002 + 8.525 x , R =0.55. P =0.021). These data suggest that the concentration of sICAM‐1 in serum increases during psoriatic inflammation. The origin and function of sICAM‐1 in psoriasis remain to be defined.