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Experience with tretinoin therapy in temperate regions
Author(s) -
CAPUTO R.,
MONTI M.,
RIGONI C.,
PINELLI S.,
MOTTA S.,
BARBARESCHI M.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb16990.x
Subject(s) - medicine , tretinoin , dermatology , regimen , sun protection , surgery , biochemistry , retinoic acid , chemistry , gene
Summary In a previously reported study on the anti‐photoageing effects of topical tretinoin, the following regimen produced good patient compliance: 0·01% for 1 month, 0·025% for 1 month; and 0·05% for 4 months. The majority of patients (60/89) enrolled in the initial study continued to apply the cream to the face, and a further 140 patients were enrolled for a long‐term study (mean duration 2 years). The prolonged study showed that 91·4% of patients used tretinoin in an attempt to slow down skin ageing, and 8·6% sought subjective skin benefits. Of the 163 patients who completed the study, 58·8% sought an improvement of wrinkles, 30·1% skin trophism and 14·7% reduced pigmentation. The product was used throughout the year by 66·9% of patients, but 8·0% stopped using it during the summer. A daytime moisturizing cream was required by 77·9% of patients, and 82·8% used a sunscreen in the summer. Tretinoin was applied to other areas of the body by 63·8% of patients.