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The effect of zinc and erythromycin on the growth of erythromycin‐resistant and erythromycin‐sensitive isolates of Propionibacterium acnes : an in‐vitro study
Author(s) -
HOLLAND K.T.,
BOJAR R.A.,
CUNLIFFE W.J.,
CUTCLIFFE A.G.,
EADY E.A.,
FAROOQ L.,
FARRELL A.M.,
GRIBBON E.M.,
TAYLOR D.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb15124.x
Subject(s) - erythromycin , propionibacterium acnes , microbiology and biotechnology , tetracycline , in vitro , antibiotics , medicine , chemistry , biology , dermatology , acne , biochemistry
Summary The effect of zinc and erythromycin on cultures inoculated with mixtures of different ratios of erythromycin sensitive (E S ) and resistant (E R ) Propionibacterium acnes cells was studied in vitro. Propionibacterium acnes E S outgrew P. acnes E R in the absence of erythromycin and zinc. At low levels of erythromycin E S outgrew E S . whilst the addition of 600 pg/ml zinc further reduced the growth of E R compared to E S Growth of E R and E S were similar at levels of erythromycin near the minimum inhibitory concentration (MIC) of E S cells. Concentrations above the MIC for E s cells inhibited E S but not E R cells. At the higher concentrations of erythromycin, the addition of 96 ng/ml zinc delayed the growth of E R cells, whilst the addition of 300 μg/ml zinc prevented the growth of E R cells. The combination of erythromycin and zinc, at appropriate concentrations, inhibits both E S and E R .