The effect of topical steroids on cutaneous oxygen tension | Zendy

HARIA M. | Zendy; O'NEILL R.C. | Zendy; WRIGHT S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

The effect of topical steroids on cutaneous oxygen tension

Author(s) -

HARIA M.,

O'NEILL R.C.,

WRIGHT S.

Publication year - 1992

Publication title -

british journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.304

H-Index - 179

eISSN - 1365-2133

pISSN - 0007-0963

DOI - 10.1111/j.1365-2133.1992.tb15123.x

Subject(s) - medicine , dermatology , oxygen tension , oxygen , chemistry , organic chemistry

Summary The precise mode of action of topically applied steroids is unknown. We have applied clobetasol propionate 0·05% ointment (Dermovate® Glaxo Pharmaceuticals) under occlusion to the forearm skin of 10 healthy volunteers for 6 hand monitored transcutaneous oxygen tension at the site for 19 h after its removal. Compared to the ointment base, the steroid‐treated area was significantly hypoxic up to 13 h after application. The profound hypoxia present at the site of application of clobetasol propionate 0·05% ointment may account for some of its anti‐inflammatory effects, and its atrophogenicity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research