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Density and morphology of Langerhans cells in basal cell carcinomas of the face and trunk
Author(s) -
BHRGFELT L.,
LARKÖ O.,
LINDBERG M.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb14868.x
Subject(s) - epidermis (zoology) , langerhans cell , pathology , basal (medicine) , trunk , basal cell carcinoma , morphology (biology) , biology , cell , anatomy , basal cell , medicine , antigen , endocrinology , immunology , ecology , genetics , insulin
Summary We investigated the density and morphology of Langerhans cells in epidermal sheets of basal cell carcinomas in chronically sun‐exposed skin (face) and less exposed skin (trunk) of 65 patients. Langerhans cells in perilesional and control skin at the same anatomical sites as the tumours were also examined. Two markers (ATPase and OKT6) were used in a parallel fashion to identify Langerhans cells. The density of the cells was reduced, and their morphology was changed in epidermis overlying tumours of both the face and trunk. These alterations were confined to tumour areas, as Langerhans cells in perilesional skin were normal when compared with control skin at both anatomical sites. Results with both markers were the same.