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Humoral responses to Malassezia furfur serovars A, B and C in normal individuals of various ages
Author(s) -
CUNNINGHAM A.C.,
INGHAM E.,
GOWLAND G.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb14843.x
Subject(s) - malassezia , serotype , microbiology and biotechnology , fungi imperfecti , medicine , dermatology , biology
Summary A transferable solid‐phase (TSP) ELISA was developed for the determination of antibody titres specific to Malassezia furfur serovars A, B and C in human sera. A survey of levels of class‐specific antibodies (IgM, IgG and IgA) to M. furfur serovars A, B and C in relation to age (2–64 years: 60 individuals) demonstrated that individuals had immunity to M. furfur by the age of 2–3 years. There was no difference in either IgM or IgG levels into adulthood. The only age‐related differences were lower IgM titres to the three serovars in the 60–64 year age‐group compared with younger individuals. There was, however, a difference between titres of antibody specific to the three serovars. The mean reciprocal log 2 IgM titre to serovar A (6·9) was significantly higher (P < 0·05) than that to serovar B (mean reciprocal log 2 titre of 5·8), but not to serovar C (6·1). In contrast, the mean reciprocal log 2 IgG titre to serovar A (6·5) was significantly lower (P <0 ·05) than those to serovars B and C (mean reciprocal log 2 titre of 8·9 in both cases).