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Stereological studies of desmosomes in ichthyosis vulgaris
Author(s) -
ELSAYEDALI H.,
BARTON S.,
MARKS R.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb08398.x
Subject(s) - ichthyosis vulgaris , ichthyosis , desquamation , stratum corneum , dyskeratosis , pathology , dermatology , hyperkeratosis , medicine , biology , anatomy , atopic dermatitis , filaggrin
Summary Standardized stereological methods were performed on biopsies from three subjects with normal skin and from three patients with autosomal dominant and three with autosomal recessive sex‐linked ichthyosis to determined the relative numbers and dimensions of desmosomes. The results showed an increase in the persistence of desmonsomes in the stratum corneum in both ichthyotic groups. This suggests a pathogenetic role for desmosomes in the abnormal desquamation of the two types of ichthyosis vulgaris.