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Blood transfusions in the therapy of a case of prolidase deficiency
Author(s) -
BERARDESCA E.,
FIDELI D.,
BELLOSTA M.,
DYNE K.M.,
ZANABONI G.,
CETTA G.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb07820.x
Subject(s) - urinary system , medicine , blood transfusion , excretion , endocrinology , gastroenterology
Summary A case is reported of a 15‐year‐old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly‐pro. Prolidase activity of erythrocytes against substrate glycyl‐proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity and declined to 12% and 3.4% of normal activity after 8 and 45 days, respectively. Urinary iminodipeptide levels following transfusion remained unaltered.