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Topical 5‐aminosalicylic acid: a treatment for aphthous ulcers
Author(s) -
COLLIER P.M.,
NEILL S.M.,
COPEMAN P.W.M.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb07818.x
Subject(s) - medicine , placebo , aminosalicylic acid , dermatology , placebo group , double blind , gastroenterology , surgery , alternative medicine , pathology
Summary A double‐blind placebo controlled trial of 5% 5‐aminosalicylic acid (5‐ASA) cream for the treatment of oral aphthous ulcers was carried out on 22 subjects. The cream or a placebo (11 patients each) was applied to the ulcers three times daily for up to 14 days. Daily discomfort was reduced by half ( P <0.01) and less pain ( P <0.05) was experienced by the treated group. Treatment with 5‐ASA shortened healing time (7 vs. 11 days, P <0.01) and reduced the difficulty in eating ( P <0.05). No significant side‐effects were reported. We believe 5‐ASA cream to be an effective treatment for aphthous ulcers.