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CD8 + cutaneous anaplastic large‐cell lymphoma: report of two cases with immunophenotyping, T‐cell‐receptor gene rearrangement and electron microscopic studies
Author(s) -
KIKUCHI A.,
SAKURAOKA K.,
KURIHARA S.,
AKIYAMA M.,
SHIMIZU H.,
NISHIKAWA T.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb00690.x
Subject(s) - immunophenotyping , gene rearrangement , lymphoma , anaplastic large cell lymphoma , anaplastic lymphoma kinase , cd8 , pathology , medicine , cancer research , gene , biology , immunology , flow cytometry , genetics , antigen , malignant pleural effusion , lung cancer
Summary Two cases are reported of cutaneous anaplastic large‐cell lymphoma with the suppressor/cytotoxic (CD8) phenotype. In both cases there was a solitary skin tumour in which there was a dense infiltrate with large irregularly shaped cells which on immunophenotyping expressed CD8. DNA hybridization analysis showed rearrangements of the T‐cell‐receptor gene in both cases.