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Oral intraepidermal IgA pustulosis and Crohn's disease
Author(s) -
BORRADORI L.,
SAADA V.,
RYBOJAD M.,
FLAGEUL B.,
KUFFER R.,
LÉMANN M.,
VEROLA O.,
MODIGLIANI R.,
MOREL P.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb00685.x
Subject(s) - medicine , histopathology , pathology , biopsy , immunofluorescence , direct fluorescent antibody , oral mucosa , autoantibody , crohn's disease , stratum spinosum , dermatology , disease , immunology , antibody , stratum corneum
Summary A case is reported of a 60‐year‐old woman with Crohn's disease who developed recurrent oral blisters and erosions. The histopathology of the buccal mucosa showed intraepidermal bullae and clefts with an intense accumulation of neutrophils in the epithelium. Direct immunofluorescence revealed intercellular IgA predominantly in the basal and suprabasal layers and in one biopsy concurrent deposits of IgG. No circulating autoantibodies were detected.