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A case of skin hyperpigmentation due to α‐MSH hypersecretion
Author(s) -
PEARS J.S.,
JUNG R.T.,
BARTLETT W.,
BROWNING M.C.K.,
KENICER K.,
THODY A.J.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb00660.x
Subject(s) - hyperpigmentation , medicine , dermatology , pigmentation disorder , skin hyperpigmentation
Summary A case is presented of generalized skin hyperpigmentation due to α‐MSH hypersecretion from the pituitary that was most marked in the light‐exposed areas. The patient also had secondary adrenal dysfunction, peripheral lymphadenopathy, streptococcal glomerulonephritis and malabsorption. Analysis of this patient's α‐MSH using high‐pressure liquid chromatography (HPLC) showed a novel acetylation profile compared to normal individuals and to patients with Cushing's disease and Nelson's syndrome. Glucocorticoid replacement therapy resulted in suppression of α‐MSH hypersecretion and complete resolution of the illness.