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Increased calmodulin levels in fibroblasts from progressive systemic sclerosis
Author(s) -
SEISHIMA M.,
NAGAO S.,
KUWAHARA M.,
MORI S.,
NOZAWA Y.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb00650.x
Subject(s) - calmodulin , radioimmunoassay , phosphodiesterase , fibroblast , pathogenesis , endocrinology , medicine , immunology , chemistry , calcium , biochemistry , enzyme , in vitro
Summary Calmodulin levels in cultured skin fibroblasts from patients with progressive systemic sclerosis (PSS) and healthy controls were measured by their ability to activate cyclic AMP‐phosphodiesterase. Calmodulin levels were significantly increased in PSS fibroblasts compared with normal control fibroblasts. The changes in calmodulin content of PSS fibroblasts were also assessed by a radioimmunoassay. These findings suggest that an elevated of calmodulin may play a role in the pathogenesis of PSS.