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Bath‐water compared with oral delivery of 8‐methoxypsoralen PUVA therapy for chronic plaque psoriasis
Author(s) -
LLINS P.C.,
GERS S.R.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb00460.x
Subject(s) - puva therapy , plaque psoriasis , psoriasis , methoxsalen , medicine , dermatology , psoralen , chemistry , dna , biochemistry
Summary Forty‐four patients with chronic plaque psoriasis were randomly allocated to treatment with bathwater‐delivered 8‐methoxypsoralen (bath 8‐MOP) or oral 8‐methoxypsoralen (oral 8‐MOP) PUVA therapy. There was a significant reduction in extent of the lesions and psoriasis area and severity index (PASI) after 20 treatments with each modality. There was a fourfold reduction in cumulative ultraviolet A (UVA) dose in the bath group. Side‐effects of erythema and nausea were less with bath therapy.