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Ultraviolet light induction of peripheral granulocytosis with splenomegaly: protection of mice with topical p ‐aminobenzoic acid (PABA)
Author(s) -
FLINDTHANSEN H.,
EBBESEN P.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb14744.x
Subject(s) - granulocytosis , hairless , spleen , ultraviolet light , chemistry , medicine , endocrinology , biology , immunology , granulocyte , biochemistry , photochemistry
Summary Hairless mice were exposed to UVB irradiation from a Philips T1 12 light source. Mice that were exposed to UV‐light and not protected with 5% p ‐aminobenzoic acid (PABA) showed a significantly higher number of peripheral blood granulocytes ( P <0·001) and a significantly higher mean weight of both the spleen and the liver ( P <0·001) than the non‐irradiated controls. light microscopy of the histology of the enlarged liver and spleen showed a proliferation of granulocytes and the reticuloendothelial cells. Treatment with topical PABA during the whole period of UV‐exposure prevented the peripheral blood granulocytosis. These protected mice also had a significantly (P <0·001) lower mean weight for the liver and spleen than UV‐exposed and non‐protected mice.