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Prurigo pigmentosa: role of ICAM‐1 in the localization of the eruption
Author(s) -
TERAKl Y.,
SHIOHARA T.,
NAGASHIMA M.,
NISHIKAWA T.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb14172.x
Subject(s) - medicine , dermatology
Summary Immunohistochemical studies were carried out on the skin lesions of two cases of prurigo pigmentosa. There was a predominance of CD4 + cells in the dermal infiltrate, whereas those lymphocytes in the epidermis were mainly CD8 + cells. The majority of dermal and epidermotropic lymphocytes showed an intense expression of lymphocyte function‐associated antigen 1 (LFA‐1). The number of CD1 + cells was increased in the epidermis. There was intense expression of ICAM‐1 by keratinocytes in the erythematous papules. Focal expression of ICAM‐1 was still observed in the residual pigmented areas and could explain the recurrence of the lesions at these sites.