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In‐vivo administration of recombinant IL‐2 increases the number of Thy‐1 + dendritic epidermal cells
Author(s) -
IBAGAKI N.S.,
TAMAKI K.,
SHIMADA S.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb06057.x
Subject(s) - in vivo , recombinant dna , dendritic cell , medicine , immunology , biology , gene , immune system , genetics
Summary The number, morphology and response of Thy‐1 + dendritic epidermal cells to recombinant interleukin‐2 (rIL‐2) were investigated in young and aged mice. The Thy‐1 + dendritic cells in the aged mice continued to express T‐cell receptor (TCR) γ/δ but differed morphologically from those of the young mice. The aged mice had 50% fewer cells than the young ones. In the rIL‐2 treated mice all the Thy‐1 + cells were expressed as TCR γ/δ and exposure to rlL‐2 increased the number of these cells in a time‐ and dose‐dependent manner when given systemically and locally. In the aged mice daily injection of rlL.‐2 increased the number of Thy‐1 + dendritic cells within 2 weeks to almost that of young mice. however they had a lower response in the earlier stage. Nude mice showed no response to rIL‐2.