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The induction of epidermal ornithine decarboxylase following tape stripping is inhibited by a topical vitamin D3 analogue (MC903)
Author(s) -
ARNOLD W. P.,
KERKHOF P. C. M.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb06029.x
Subject(s) - ornithine decarboxylase , psoriasis , medicine , vitamin , placebo , endocrinology , pharmacology , dermatology , chemistry , enzyme , pathology , biochemistry , alternative medicine
Summary The efficacy of MC903, a vitamin D3 analogue, in reducing hyperproliferation as determined by levels of ornithine decarboxylase (ODC) was investigated in a double‐blind study of 15 patients with chronic plaque psoriasis. The lesions of psoriasis were treated for 8 weeks with MC903 in one of two different cream bases or with a placebo cream. Biopsies were taken before and after treatment. In addition an uninvolved area of skin was treated during the last 3 weeks and this as well as control areas were then sellotape stripped and biopsied after 8 h. Clinical improvement was seen in eight out of 11 patients treated with MC903 but there was no reduction in the level of ODC in psoriatic lesions after 8 weeks of treatment. The levels of ODC in the tape‐stripped uninvolved skin after 3 weeks of treatment with MC903 averaged 22·5 ± 4.2 pmol/min/mg protein as compared to 58·6 ± 12·6 pmol/min/mg protein ( P = 0·004). The trauma‐induced induction of ODC activity was markedly inhibited by the application of MC903.