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Allergic contact and photocontact dermatitis due to psoralens in patients with psoriasis treated with topical PUVA
Author(s) -
TAKASHIMA A.,
YAMAMOTO K.,
KIMURA S.,
TAKAKUWA Y.,
MIZUNO N.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb03279.x
Subject(s) - dermatology , psoriasis , medicine , erythema , incidence (geometry) , allergic contact dermatitis , contact dermatitis , psoralen , patch test , puva therapy , allergy , immunology , chemistry , dna , biochemistry , physics , optics
Summary The incidence and clinical features of allergic contact and/or photocontact dermatitis due to psoralens were examined in 371 patients with psoriasis treated with topical PUVA. The psoralen derivatives used in the study were 8‐methoxypsoralen (8MOP), 3‐carbethoxypsoralen (3CPs), 4,6,4′‐trimethylangelicin (TMA) and 7‐methyl pyridopsoralen (MPP). Of 371 patients treated with 8MOP, three (0.8%) developed an acute dermatitis in the PUVA‐treated areas. This incidence was significantly lower ( P <0.01) than that for 3CPs (four of 10 patients) or that for TMA (six of 17 patients). None of the seven patients receiving MPP on PUVA had a reaction. It was confirmed that these dermatitis reactions were due to contact and/or photocontact allergy to psoralens by several methods that included patch and photopatch tests, photopatch test mapping, determination of the minimal erythema dose (MED) and immunohistochemistry.