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The treatment of vulval lichen sclerosus with a very potent topical steroid (clobetasol Propionate 0.05%) cream
Author(s) -
DALZIEL K.L.,
MILLARD P.R.,
WOJNAROWSKA F.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb00626.x
Subject(s) - clobetasol propionate , lichen sclerosus , dermatology , topical steroid , medicine , testosterone propionate , psoriasis , androgen , hormone
Summary The clinical and histological response to 12 weeks of treatment with a very potent topical fluorinated steroid was studied in 15 patients with vulval lichen sclerosus (LS) who were treated with twice eaily applications of clobetasol propionate 0.05% cream (Dermovate, Glaxo U.K.), Thirteen patients completed the study and all showed a marked clinical improvement. Histological measurements of skin biopsies taken before and after treatment showed a significant reduction in the characteristic features of LS. One patient developed contact sensitivity to clobetasol propionate. There was no evidence of infection or skin atrophy during the study. Patients completing the study have been followed up for up to 22 months and have been maintained in remission with moderately potent topical steroids which had previously been ineffective.