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Absorption of hydrocortisone from the skin reservoir in atopic dermatitis
Author(s) -
TURPEINEN M.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb00597.x
Subject(s) - moisturizer , hydrocortisone , atopic dermatitis , dermatology , absorption (acoustics) , medicine , chemistry , food science , materials science , composite material
Summary Percutaneous absorption of hydrocortisone was measured in four children and three adults with atopic dermatitis after the application of 1% hydrocortisone cream and again 12 h alter the application of a moisturizer containing 80% water and 5% propylene glycol to the same areas. A significant increase in the level of the plasma cortisol was observed after both applications and these levels were still elevated at 24 h. Topically applied hydrocortisone. Stored in eczematous skin, could be released from this reservoir by a moisturizer containing propylene glycol.