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Glomus tumours of the skin: an immunohistochemical investigation of the expression of marker proteins
Author(s) -
HERBST W. M.,
NAKAYAMA K.,
HORNSTEIN O. P.
Publication year - 1991
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1991.tb00428.x
Subject(s) - immunohistochemistry , enolase , pathology , neurofilament , vimentin , sprouting , glomus , glomus cell , biology , glomus tumor , antibody , anatomy , receptor , medicine , immunology , botany , biochemistry , chemoreceptor , inoculation
Summary Immunohistochemical studies were carried out on cutaneous glomus tumours from 10 patients. The glomus areas in these tumours reacted strongly with anti‐smooth muscle (CGA‐7), anti‐muscle (HHF‐35) and anti‐vimentin antibodies. Their neural supply was analysed using several nervous tissue markers (anti‐neurone specific enolase, anti‐S 100, anti‐Leu 7, anti‐neurofilaments). The results indicate a sprouting and proliferation rather than entrapment of pre‐existing nerve fibres.