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Sunlight‐induced cancer: some new aspects and implications of the xeroderma pigmentosum model
Author(s) -
LEHMANN A. R.,
BRIDGES B. A.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb16136.x
Subject(s) - xeroderma pigmentosum , unit (ring theory) , dermatology , medicine , library science , cancer research , history , genetics , biology , dna , dna repair , psychology , computer science , mathematics education
SUMMARY Symptoms of xeroderma pigmentosum, a hereditary disease characterized by accelerated light‐induced ageing of the skin, are due to deficiencies in the repair of damaged DNA. Following UV irradiation a high incidence of thioguanine‐resistant mutations have been observed, which may be a model for the abnormally high incidence of freckling and benign and malignant transformation observed in these patients. Cells from patients with Cockayne's syndrome and trichothiodystrophy have also been shown to be hypermutable by UV radiation with a similar DNA repair defect, but unlike xeroderma pigmentosum patients they do not experience a higher incidence of skin cancer or freckling. An immunological defect may be a further crucial factor determining the dermatological symptoms of xeroderma pigmentosum patients.