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The antipruritic effect of a sedative and a non‐sedative antihistamine in atopic dermatitis
Author(s) -
WAHLGREN CF.,
HÄGERMARK Ö.,
BERGSTRÖM R.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb14732.x
Subject(s) - sedative , antihistamine , medicine , atopic dermatitis , terfenadine , antipruritic , dermatology , placebo , anesthesia , sedation , allergy , pharmacology , immunology , alternative medicine , pathology
SUMMARY A double‐blind, randomized, cross‐over study was carried out on the effect of a sedative and a non‐sedative antihistamine on 25 adults with atopic dermatitis. Intensity of itch was recorded using a computerized method for self‐assessment (Pain‐Track®) and using conventional visual analogue scales. The antipruritic effect of 3 days of treatment with the non‐sedative H, antagonist terfenadine (60 mg b.i.d.) and with the sedative antihistamine, clemastine (2 mg b.i.d.) did not differ from that found with the placebo. Our findings support the view that histamine is not of importance in the pathogenesis of itch in atopic dermatitis.