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Cutaneous reactions to substance P and histamine in atopic dermatitis
Author(s) -
COULSON I. H.,
HOLDEN C.A.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb08282.x
Subject(s) - atopic dermatitis , histamine , substance p , medicine , dermatology , neuropeptide , receptor
SUMMARY The flare and weal reactions to intradermal injections of histamine and the peptide substance P were measured in a group of patients with atopic dermatitis and compared to reactions in a non‐atopic control group. There was no significant difference in the flare areas between the controls and atopies with either reagent. The weal volumes after injection of substance P and histamine were significantly larger in the atopic group. As substance P causes mast cell histamine release, the increased weal volumes produced by substance P in the atopies may be entirely due to the exaggerated atopic weal reaction to histamine.