Are ACA and Scl 70 antibodies mutually exclusive? | Zendy

JARZABEKCHORZELSKA MARIA | Zendy; BŁASZCZYK MARIA | Zendy; KOŁACIŃSKASTRASZ ZOFIA | Zendy; JABŁONSKA STEFANIA | Zendy; CHORZELSKI T. | Zendy; MAUL G.G. | Zendy

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Are ACA and Scl 70 antibodies mutually exclusive?

Author(s) -

JARZABEKCHORZELSKA MARIA,

BŁASZCZYK MARIA,

KOŁACIŃSKASTRASZ ZOFIA,

JABŁONSKA STEFANIA,

CHORZELSKI T.,

MAUL G.G.

Publication year - 1990

Publication title -

british journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.304

H-Index - 179

eISSN - 1365-2133

pISSN - 0007-0963

DOI - 10.1111/j.1365-2133.1990.tb08266.x

Subject(s) - antibody , serology , scleroderma (fungus) , immunofluorescence , immunodiffusion , antigen , medicine , indirect immunofluorescence , immunology , connective tissue disease , virology , autoimmune disease , inoculation

SUMMARY Serological studies using indirect immunofluorescence, double immunodiffusion and immunoblot with recombinant Topo I and kinetochore antigens were performed in 180 patients with systemic scleroderma. In the sera of 10 patients, we found coexisting ACA and Scl 70 antibodies, and this was confirmed by all three methods. The relationship between the coexistence of these antibodies and the clinical features of the disease is not clear, although in all these cases there was pronounced vascular involvement.

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