Premium
A dose‐response study of UVB‐induced suppression of contact photosensitivity in the mouse
Author(s) -
SHIVJI G.M.,
BROWN W.R.,
RAMSAY C.A.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb08260.x
Subject(s) - photosensitivity , sensitization , phototoxicity , cyclophosphamide , dermatology , medicine , irradiation , chemistry , immunology , materials science , optoelectronics , chemotherapy , physics , biochemistry , in vitro , nuclear physics
SUMMARY A marked contact photosensitivity (CPS) response to 3, 3′, 4′, 5 tetrachlorosalicylanilide (TCSA) plus UVA was induced in mice. Cyclophosphamide (Cy), given prior to sensitization, caused a further increase in ear swelling. When UVB radiation was given at a site distant from that used for sensitization it caused a dose‐related suppression of CPS. Cy did not eliminate the UVB‐induced suppression.