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The effect of photochemotherapy with 4,4,6 trimethylangelicin on murine cutaneous immune cells
Author(s) -
ALCALAY J.,
ACQUA F.DALL',
KRIPKE MARGARET L.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb08233.x
Subject(s) - phototoxicity , furocoumarin , immune system , immunology , hyperpigmentation , medicine , microbiology and biotechnology , chemistry , dermatology , biology , in vitro , biochemistry , dna
SUMMARY The effect of photochemotherapy with 4,4′,6 trimethylangelicin (TMA), a new monofunctional furocoumarin with a high antiproliferative activity, was studied on murine dendritic epidermal cells. Female mice (C 3 H/HeN[MTV‐]) were treated topically with the drug three times a week for 4 consecutive weeks followed each time by I J/cm 2 of UVA radiation. At the end of the treatment almost total depletion of ATPase + , Ia + and Thy‐I + dendritic epidermal cells was observed, associated with marked hyperpigmentation but no gross or microscopic phototoxicity. Although 4,4′,6 TMA is not phototoxic in mice, it affects the cutaneous immune cells.