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Renal function after long‐term low‐dose cyclosporin for psoriasis
Author(s) -
POWLES A.V.,
CARMICHAEL D.,
HULME B.,
THOMAS E.,
McFADDEN J.,
BAKER B.,
VALDIMARSSON H.,
FRY L.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb07288.x
Subject(s) - medicine , library science , classics , history , computer science
SUMMARY Two groups of patients receiving cyclosporin A (CyA) for psoriasis had their renal function assessed by measurement of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). The first group comprised 13 patients who had taken low dose (average 3 mg/kg per day) CyA for an average period of 25 years. Seven of the 13 had a normal GFR of 108 (77–121) ml/min (median; range). In the other six patients the GFR was low at 63 (50–77) ml/min and CyA was discontinued for periods ranging from 3 to 17 weeks. The GFR rose in all six patients, to 79 (60–91) ml/min; this change was significant (P