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Discoid lupus erythematosus‐like lesions in carriers of X‐linked chronic granulomatous disease
Author(s) -
SMITT J.H.SILLEVIS,
WEENING R.S.,
KRIEG S.R.,
BOS J.D.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb07286.x
Subject(s) - discoid lupus erythematosus , medicine , immunophenotyping , chronic granulomatous disease , pathology , lupus erythematosus , immunology , cd3 , histopathology , monoclonal antibody , cd8 , dermatology , antibody , flow cytometry , antigen
SUMMARY A questionnaire was sent to 16 carriers of the X‐linked cytochrome‐b 558 negative variant of chronic granulomatous disease (CGD). Of the 15 who answered the questionnaire and from data of one additional case, 70% reported recurrent aphthous stomatitis and 63% had recurrent skin eruptions. Five of the carriers (31%) had clinically discoid lupus erythematosus (DLE), although the histopathology was not typical and the immunofluorescence findings were negative. The infiltrate in the lesional skin of three of these patients was analysed using monoclonal antibodies against CD 3 , CD 4 , CD8, CD Ia , HLA‐DR, CD Ic , interdigitating cells, B lymphocytes and cells of the monocyte/macrophage lineage. The immunophenotype of the infiltrating cells resembled that found in discoid lupus erythematosus.