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Skin exudate levels of interleukin 6, interleukin i and other cytokines in mycosis fungoides
Author(s) -
LAWLOR FRANCES,
SMITH N.P.,
CAMP R.D.R.,
BACON K.B.,
BLACK ANNE KOBZA,
GREAVES M.W.,
GEARING A.J.H.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb06288.x
Subject(s) - mycosis fungoides , cytokine , interleukin , pathology , lymphocyte , immunology , interleukin 2 , infiltration (hvac) , tumor necrosis factor alpha , pathogenesis , medicine , interferon gamma , lymphoma , physics , thermodynamics
SUMMARY The role of locally released cytokines in inducing lymphocyte activation and infiltration in the skin lesions of mycosis fungoides has been investigated. The levels of selected cytokines were measured in chamber fluid samples from lesional and control skin. Biologically active interleukin 6 was significantly elevated in lesional samples and a recombinant form of this cytokine was shown to induce lymphocyte migration in an in vitro assay. Biologically active interleukin 1 was detected in all control chamber fluid samples. Significantly reduced levels of this cytokine were present in lesional samples, which may be the result of the release of preformed material. Interleukin 2 and tumour necrosis factor activity, and γ interferon and granulocyte macrophage colony‐stimulating factor immunoreactivity, were not detectable in any of the samples. Interleukins 1 and 6 may play a role in the pathogenesis of the lesional lymphocyte infiltrates in mycosis fungoides.