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DNA content and K s 8.12 binding of the psoriatic lesion during treatment with the vitamin D 3 nalogue MC903 and betamethasone
Author(s) -
MARE S.DE,
JONG E.G.J.M.DE,
KERKHOF P.C.M.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb06287.x
Subject(s) - betamethasone , lesion , medicine , dermatology , vitamin , dna , endocrinology , pathology , chemistry , biochemistry
SUMMARY Twenty patients with psoriasis were treated with the vitamin D 3 analogue MC 903 and betamethasone ointment in a double‐blind trial with a left‐right comparison. In addition to the clinical severity scores, K s 8.12 binding which detects keratin 16 expression and the DNA synthesis were quantified using flow cytometry. Both markers decreased significantly with treatment, but remained above the normal range even in those who had total clearance of the lesions. Treatment with MC 903 with regard to K s 8–52 binding was significantly better than with betamethasone.