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Elucidation of chemical compounds responsible for foot malodour
Author(s) -
KANDA F.,
YAGI E.,
FUKUDA M.,
NAKAJIMA K.,
OHTA T.,
NAKATA O.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb06265.x
Subject(s) - foot (prosody) , chemistry , valeric acid , fatty acid , gas chromatography , gas chromatography–mass spectrometry , chromatography , food science , mass spectrometry , organic chemistry , philosophy , linguistics , butyric acid
summary Short‐chain fatty acids from the socks and feet of subjects either with strong foot odour or with weak or no foot odour were extracted with ethyl ether, and then analysed by gas chromatography/mass spectrometry (GC/MS). Short chain fatty acids were found in greater amounts from those subjects with strong foot odour. Iso‐valeric acid was present in all the subjects with foot odour but was not detected in those without. Olfactory evaluations of the various shortchain fatty acid solutions were in agreement with the GC/MS analyses. By incubating sweat and lipid from subjects with strong foot odour, we succeeded in reproducing the foot malodour. GC/ MS analyses of reproduced foot odour revealed that short‐chain fatty acids were present in a similar composition to that found in vivo .