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Factor XIIIa in nodular malignant melanoma and Spitz naevi
Author(s) -
KAREN J.DENTON,
COTTON D.W.K.,
WRIGHT A.,
HIRD PATRICIA
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb04197.x
Subject(s) - wright , medicine , dermatology , art history , history
SUMMARY The distribution of factor XIIIa‐positive dermal dendritic cells was studied in a series of nodular malignant melanomas and compared with that seen in Spitz naevi. Two patterns of distribution were recognizable: (a) diffusely spread through the tumour and (b) located mainly at the periphery of the tumour. These did not correlate with the diagnosis of melanoma or Spitz naevus and the distribution appeared to be a function of growth pattern of the tumour. The diffuse pattern was the most common regardless of diagnosis and the distribution of factor XIIIa‐positive cells is the same in malignant melanoma and Spitz naevi.