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Epidermal dendritic S100 positive cells in necrobiosis lipoidica and granuloma annulare
Author(s) -
CHAMBERS BRONWEN,
MILLIGAN A.,
FLETCHER A.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb04194.x
Subject(s) - necrobiosis lipoidica , granuloma annulare , epidermis (zoology) , dermatology , medicine , pathology , anatomy , diabetes mellitus , endocrinology
SUMMARY Using an antibody to S100 protein, the number of dendritic cells above the basal layer in the epidermis was assessed in necrobiosis lipoidica and granuloma annulare. A statistically significantly higher number of these cells was found within the epidermis in necrobiosis lipoidica compared with granuloma annulare and normal skin. The numbers were similar to those seen in sarcoidosis and tuberculous reactions in the skin, which raises the possibility of an immune pathogenesis for necrobiosis lipoidica.