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Female predominance of immune response to SSA/Ro antigens and risk of neonatal lupus erythematosus
Author(s) -
MIYAGAWA S.,
DOHI K.,
YOSHIOKA A.,
SHIRAI T.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb01850.x
Subject(s) - medicine , family medicine , dermatology
summary Eight‐hundred and twenty‐five patients attending the hospital with clinical signs and symptoms of collagen diseases were tested for anti‐SSA/Ro antibody. The frequency of positivity to SSA/Ro was significantly higher in females, 11.0%, than in males, 3.2% ( P <0.01). Five babies born to anti‐SSA/Ro positive mothers all had neonatal lupus erythematosus and in one there were various cardiac abnormalities.