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Epidermal growth factor receptors in human epidermal tumours
Author(s) -
NAZMI M.N.,
DYKES P.J.,
MARKS R.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb01842.x
Subject(s) - pathology , epidermal growth factor , epidermal growth factor receptor , staining , cell , autocrine signalling , receptor , biology , medicine , genetics
summary Immunolocalization studies using the strepavidin/biotin peroxidase system were used to identify epidermal growth factor receptors in 10 samples of normal skin, 13 seborrhoeic warts (SW), five lesions of Bowen's disease (BD), 11 solar keratoses (SK), 22 basal cell carcinomas (BCC) and five squamous cell carcinomas (SCC). The intensity of cell membrane staining was assessed using the 10‐cm visual analogue scale technique and the results analysed using non‐parametric statistics. The cell membranes in BCC showed significantly less intense staining when compared to normal epidermal cells ( P <0.001) and the constituent cells of SW ( P <0.0001), SK ( P <0.001), BD ( P <0.01), and SCC ( P <0.001). Classification of the specimens into normal, benign, premalignant and malignant indicated that cell membranes of malignant tumours showed significantly less staining than the other groups ( P <0.001). The observed reduction in the epidermal growth factor receptors in malignant tumours may be due to occupation and down regulation in response to autocrine secretion of growth factors.