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The presence of autoantibody to recombinant lipocortin‐I in patients with psoriasis and psoriatic arthritis
Author(s) -
RIVERS J.K.,
PODGORSKI M.R.,
GOULDING N.J.,
WONG E.,
MCGRATH J.A.,
FLOWER R.J.,
GREAVES M.W.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb01472.x
Subject(s) - psoriatic arthritis , medicine , psoriasis , dermatology , library science , computer science
SUMMARY Corticosteroids may mediate some of their anti‐inflammatory effects via induction of a specific 38 kDa protein, lipocortin‐I. Anti‐lipocortin‐I antibodies (ALA) were measured by enzymelinked immunosorbent assay (ELISA) in 23 patients with plaque‐type psoriasis alone (NAP), in 21 patients with psoriasis and arthritis (PA), and in 67 healthy controls. Only two of 23 NAP patients had elevated ALA, whereas six of 21 PA patients had raised levels of ALA ( P = 0.2). Sero‐negative polyarthritis was the most common pattern of joint disease in those PA patients with elevated ALA (4/6). ALA levels did not correlate with the extent or severity of cutaneous involvement, and are unlikely to be involved in the pathogenesis of cutaneous psoriasis.