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Autoantibodies to nucleolar antigens in systemic scleroderma: clinical correlations
Author(s) -
BLASZCZYK MARIA,
JARZABEKCHORZELSKA MARIA,
JABLONSKA STEFANIA,
CHORZELSKI T.,
KOLACINSKASTRASZ ZOFIA,
BEUTNER E.H.,
KUMAR V.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb01445.x
Subject(s) - medicine , library science , state (computer science) , dermatology , algorithm , computer science
SUMMARY Indirect immunofluorescence (IIF) and double immunodiffusion (DID) were performed on the sera of 64 patients who had a nucleolar immunofluorescence pattern on HEp‐2 cells. Forty‐nine of the sera were from 296 patients with systemic scleroderma (SSc) and 15 sera were from 214 patients with systemic lupus erythematosus (SLE). A homogeneous nucleolar staining pattern was found in 45 of the 64 sera (70.3%), a clumpy fluorescence associated with fibrillarin antibody in 14 (21.8%) and a speckled pattern was found in five of the sera (7.8%). There was a clear correlation between the sera which showed a homogeneous nucleolar staining pattern with symptoms of the polymyositis/scleroderma overlap syndrome that differed from SSc with concomitant myositis. The clumpy pattern was mainly associated with diffuse scleroderma and the speckled pattern with limited scleroderma (previously called acrosclerosis).