Premium
Potential for irritation increases from the wrist to the cubital fossa
Author(s) -
VALK P.G.M.,
MAIBACH H.I.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb08212.x
Subject(s) - transepidermal water loss , forearm , erythema , irritation , dermatology , medicine , wrist , contact dermatitis , skin irritation , surgery , stratum corneum , allergy , pathology , immunology
SUMMARY The effect of site on the irritant dermatitis potential was studied in 10 subjects using the volar surface of the forearm. Erythema scoring and transepidermal water loss (TEWL) measurements were used to assess irritation at different levels on the forearm. A sodium lauryl sulphate (SLS 2 g/v%) solution was used as a standard irritant in a patch test procedure and on open tests. Both the erythema scores and measurements of the TEWL of exposed skin showed significant localization differences, and demonstrated that the same sites on the forearm should be used for irritancy tests and possibly physiological studies.