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Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long‐term application of a potent topical corticosteroid
Author(s) -
LAWLOR FRANCES,
BLACK ANNE KOBZA,
MURDOCH R.D.,
GREAVES M.W.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb08195.x
Subject(s) - histamine , topical steroid , medicine , clobetasol propionate , corticosteroid , mast cell , intradermal injection , steroid , dermatology , pharmacology , immunology , hormone
SUMMARY Clobetasol propionate 0.05% ointment and an otherwise identical steroid‐free base were applied topically to a 10 cm 2 area on the anterior thighs of six patients with symptomatic dermographism for 6 weeks. Four patients showed a significantly decreased wealing response to stroking of steroid pretreated skin compared to that of control sites. There was a parallel decrease in mast cell numbers and histamine levels in skin biopsies taken from the steroid treated areas. At 6 weeks two patients demonstrated a decrease in flare areas following the intradermal injection of compound 48/80 in steroid pretreated skin compared to base treated sites. Flare areas following intradermal injection of histamine in these two patients were equivalent in base and steroid treated skin.