Premium
Darier's disease: an immunohistochemical study using antibodies to proteases
Author(s) -
BURGE S.M.,
RYAN T.J.,
CEDERHOLMWILLIAMS S.A.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb08193.x
Subject(s) - darier's disease , immunohistochemistry , proteases , fibrinogen , darier disease , antibody , pathology , medicine , disease , biology , immunology , enzyme , biochemistry
SUMMARY The expression of plasminogen activators, plasminogen and fibrinogen was investigated in 10 specimens of normal skin and in the involved skin of seven males with Darier's disease, using immunohistochemical techniques. Changes in the localization of proteases were found in the involved skin of Darier's disease, plasminogen being expressed by suprabasal cells and fibrinogen being detected in the keratotic plug.