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Novel variants of human papillomavirus type 2 in warts from immunocompromised individuals
Author(s) -
WILSON C.A.B.,
HOLMES S.C.,
CAMPO M.S.,
WHITE S.I.,
TILLMAN D.,
MACKIE R.M.,
THOMSON J.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb08188.x
Subject(s) - psti , common warts , human papillomavirus , virology , restriction fragment length polymorphism , viral disease , southern blot , biology , medicine , virus , dna , genotype , genetics , gene , restriction enzyme
SUMMARY Twenty cutaneous warts from 18 renal transplant recipients (RTR) and a single wart sample from a patient suffering from Hodgkin's disease were screened for the presence of human papillomavirus (HPV) sequences by Southern blot analysis. Thirteen samples were shown to contain HPV DNA sequences, one was identified as HPV‐3, two as HPV‐4, six as HPV‐2 and four were unidentifiable by restriction digest analysis. HPV‐3 was identified in the wart sample from the patient suffering from Hodgkin's disease. In the six samples in which HPV‐2 was found, the viral genome showed polymorphism for the PvuII and PstI sites. Two PvuII patterns and one PstI pattern are novel.