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Delayed pressure urticaria, objective evaluation of a variable disease using a dermographometer and assessment of treatment using colchicine
Author(s) -
LAWLOR FRANCES,
BLACK ANNE KOBZA,
WARD A. MILFORD,
MORRIS R.,
GREAVES M.W.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb04167.x
Subject(s) - colchicine , medicine , placebo , erythrocyte sedimentation rate , gastroenterology , surgery , pathology , alternative medicine
SUMMARY A randomized double‐blind placebo controlled trial of colchicine in the treatment of 13 patients with delayed pressure urticaria enabled us to assess some of the variables in this disorder. We have modified a previously described method of pressure testing using a calibrated dermograph‐ometer and shown a pressure induced papular dose response curve. Assessment of disease activity was based on the number of pressure weals which occurred, the size of delayed pressure induced papules using a dermographometer calibrated at 9.75 × 10 5 pascals for five separate time periods on the back and estimations of erythrocyte sedimentation rate and the acute phase protein levels. We have been unable to show a therapeutic effect using colchicine 0.5 mg bd for 1 week.