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Lymphomatoid papulosis: ultrastructural, immunohistochemical and gene analytical studies
Author(s) -
MATSUYOSHI N.,
HORIGUCHI Y.,
TANAKA T.,
TAKAHASHI K.,
DOSAKA N.,
FUJITA M.,
MIYACHI Y.,
IMAMURA S.
Publication year - 1989
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1989.tb01433.x
Subject(s) - lymphomatoid papulosis , immunohistochemistry , pathology , biology , hindiii , gene rearrangement , ecori , bamhi , lymphoma , microbiology and biotechnology , gene , medicine , genetics , cd30 , genome , restriction enzyme
SUMMARY Ultrastrutual, immunohistochemical and gene analytical studies were carried out on a 39‐year‐old patient with lymphomatoid papulosis. Two different cell groups were demonstrated in the papulonodular eruptions: large atypical cells with multiple nuclei that were well stained with anti‐Tac, but not with Leu 3a, and other cells that possessed prominent hyperchromatic nuclei and which stained well with Leu 1 and Leu 3a but not with anti‐Tac. Gene analytical studies using Eco RI, Bam HI and Hind III revealed no rearrangement, indicating a non‐clonal T‐cell proliferation unlike malignant T‐cell lymphoma. These results suggest that the present case was benign.